1. FSV Mainz 05 vs TSG 1899 Hoffenheim Prediction 21 November 2025

Mainz sit seventeenth with only five points and a 10:18 goal difference—a sharp decline from last season’s European push. Recent results underline the slump, including heavy defeats to Hamburg (0:4), Leverkusen (3:4) and Stuttgart (1:2), a draw with Werder (1:1), and a narrow loss to Eintracht (0:1). Defensive issues and inconsistency continue to drag the Carnivalers down the table.

Hoffenheim, by contrast, have surged after their 0:1 loss to Cologne. Wins over St. Pauli (3:0), Heidenheim (3:1), Wolfsburg (3:2) and RB Leipzig (3:1) have lifted them to sixth place with 19 points and a 21:16 goal difference. Their attack is clicking, and the side looks confident and well-balanced.

Given the form of both teams, bookmakers may be underestimating Hoffenheim. Matarazzo’s side have routinely handled opponents from the bottom half, while Mainz have yet to rediscover the structure and resilience of last season. On current momentum, the visitors look better placed to take points here.

Hoffenheim not to lose (X2) 1.65